To speak about Certified Reference Materials is in fact to talk about the quality on the results. The issue of quality in laboratories is translated into a higher or lesser uncertainty in the results. The origin of this uncertainty is varied, coming maybe from the methodology used, because of human error, due to the instruments themselves or deriving from the complexity of the sample. The main purpose of the Certified Reference Materials/Analytical Standars is to grant the users the necessary certainty to obtain exact measures, facing thus with proven and documented efficiency the requests set by the different quality assurance procedures.